Liverpool travel to Udinese looking for the win to guarantee their place in the last 32 of the Europa League.
The Reds are currently second in the group and a win over Udinese, who are already out, will ensure their progression into the knockout stages.
A draw could be good enough if Young Boys fail to beat Anzhi, but a defeat in Italy will mean an early exit from Europe for Brendan Rodgers' side even if Young Boys also lose as as the Swiss side would be top of a three-way head-to-head involving the Reds and Udinese.
Rodgers has named a strong squad with Luis Suarez set to start as he is suspended for this weekend's Premier League clash with West Ham.
Liverpool captain Steven Gerrard is missing through illness, while Daniel Agger and Lucas Leiva have been rested.
Udinese coach Francesco Guidolin could rest a number of his top stars as he looks to concentrate on Serie A.
If Antonio Di Natale plays he will equal Valerio Bertotto's Udinese record of 33 appearances in UEFA club competition.
Giampiero Pinzi is available again after injury as Udinese look to end a run of three straight defeats in the Europa League.
The squad in full is: Jones, Johnson, Enrique, Sahin, Suarez, Cole, Assaidi, Henderson, Coates, Downing, Carragher, Allen, Reina, Suso, Sterling, Shelvey, Coady, Skrtel, Wisdom.
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